杭州市部分职业人群血清非高密度脂蛋白胆固醇水平分析

低密度脂蛋白胆固醇（LDL-C）长期来被认为是致动脉粥样硬化（AS）的决定性因素和降脂治疗预防心血管疾病的首要目标。在低甘油三酯（TG）水平时，LDL-C含有大部分致AS的胆固醇；然而，当TG水平增高时，富含TG的脂蛋白、中低密度脂蛋白胆固醇（IDL-C）和极低密度脂蛋白胆固醇（VLDL-C）含有大量致AS的胆固醇，也应进行治疗。

Investigation of Serum Non-high Density Lipoprotein Cholesterol in Hangzhou Occupational Population

Objective To observe the serum level of non-high density lipoprotein cholesterol（non-HDLC）,and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people（7369 males,4299 females） who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） according to standard operating procedure.And then non-HDLC and atherogenic index of plasma（AIP） were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log（TG/HDL-C）.Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation（P〈0.001）.When TG〈4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.