| 中药萎胃康逆转慢性萎缩性胃炎的机制研究 |
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| 引用本文： | 赵岩,林海燕,于佳宁.中药萎胃康逆转慢性萎缩性胃炎的机制研究[J].滨州医学院学报,2011,0(4):241-243. |
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| 作者姓名： | 赵岩 林海燕 于佳宁 |
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| 作者单位： | 滨州医学院中西医结合学院 烟台市264003;滨州医学院烟台附属医院 |
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| 基金项目： | 国家自然科学基金资助项目(81072782) |
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| 摘 要： | 目的探讨中药萎胃康逆转慢性萎缩性胃炎（CAG）的机制。方法采用多重刺激法复制慢性萎缩性胃炎动物模型,分别应用大、小剂量萎胃康及三九胃泰灌胃治疗。30 d后观察大鼠胃酸、血清胃泌素（GAS）含量及免疫组化法观察G细胞数量,光镜下观察胃黏膜病理学改变。结果萎胃康大、小剂量组及三九胃泰组均能不同程度的升高胃酸、血清GAS含量和增加G细胞数量,以萎胃康大剂量组最为明显（P〈0.01）。结论中药萎胃康对CAG的疗效机制可能与升高胃酸、血清GAS含量和增加G细胞数量有关。
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| 关 键 词： | 慢性萎缩性胃炎 萎胃康 三九胃泰 |
Mechanism research about effect of Weiweikang-Granule on reversing rats with chronic atrophic gastritis |
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| ZHAO Yan,LIN Haiyan,YU Jianing.Mechanism research about effect of Weiweikang-Granule on reversing rats with chronic atrophic gastritis[J].Journal of Binzhou Medical College,2011,0(4):241-243. |
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| Authors: | ZHAO Yan LIN Haiyan YU Jianing |
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| Institution: | ZHAO Yan1 LIN Haiyan1 YU Jianing2 1 Department of TCM,Binzhou Medical University,Yantai 264003,2 Affiliated Yantai Hospital of Binzhou Medical University |
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| Abstract: | Objective To approach the possible mechanism of Wei wei kang-Granule(WWKG)reversing chronic atrophic gastritis(CAG).Methods The multiple stimulations were used to duplicate the CAG model.Treat respectively with WWKG and Sanjiuwei-tai-Granule(SJWTG).After 30 days,the contents of gastric acid and GAS in serum and the pathological changes of the gastric mucosa by gross appearance and microscopy were observed.The immunohistochemistry method was used to observe the number of G cell.Results The contents of gastri... |
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| Keywords: | chronic atrophic gastritis(CAG) WWKG SJWTG |
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