| 系统性红斑狼疮患者外周血CD4+CD25high Treg上PD-1分子的表达分析 |
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| 引用本文： | 王元元,陈晓蓉,刘铜,唐洁,谢长好.系统性红斑狼疮患者外周血CD4+CD25high Treg上PD-1分子的表达分析[J].蚌埠医学院学报,2011,36(11):1184-1186. |
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| 作者姓名： | 王元元 陈晓蓉 刘铜 唐洁 谢长好 |
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| 作者单位： | 安徽医科大学,组织学与胚胎学教研室,安徽,合肥,230032;蚌埠医学院,组织学与胚胎学教研室,安徽,蚌埠,233030;安徽医科大学,组织学与胚胎学教研室,安徽,合肥,230032;蚌埠医学院,组织学与胚胎学教研室,安徽,蚌埠,233030;感染与免疫安徽省重点实验室,安徽,蚌埠,233030;蚌埠医学院第一附属医院,风湿免疫科,安徽,蚌埠,233004 |
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| 基金项目： | 安徽省卫生厅青年基金资助项目(09B108) |
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| 摘 要： | 目的：检测系统性红斑狼疮（systemic lupus erythematosus,SLE）患者外周血CD4＋CD25highTreg及其程序性死亡受体-1（programmed death-1,PD-1）分子的表达,探讨Treg和PD-1表达在SLE中的意义。方法：流式细胞仪检测SLE患者组、正常对照组外周血CD4＋T细胞中的CD4＋CD25highTreg和CD4＋CD25lowT细胞的比例,及其PD-1分子的表达率。结果：CD4＋CD25highTreg在SLE患者组外周血中CD4＋T细胞的比例（0.63±0.31）%与正常对照组（2.07±0.74）%相比明显降低（P〈0.05）,该亚群细胞上PD-1＋的百分率（24.99±18.65）%与对照组（6.97±1.92）%相比显著增高（P〈0.05）;CD4＋CD25lowT细胞的百分率（13.40±8.47）%及其PD-1＋的百分率（2.70±3.06）%与正常对照组（20.16±11.89）%和（0.43±0.36）%相比,差异有统计学意义（P〈0.05）。结论：外周血CD4＋CD25highTreg数量下降及其PD-1分子表达上调可能在SLE中有重要意义。
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| 关 键 词： | 红斑狼疮 系统性 调节性T细胞 程序性死亡受体-1 |
Analysis of frequency and expression of programmed cell death-1 of CD4~+ CD25~(high) Treg peripheral blood in systemic lupus erythematosus patients |
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| WANG Yuan-yuan,CHEN Xiao-rong,LIU Tong,TANG Jie,XIE Chang-hao.Analysis of frequency and expression of programmed cell death-1 of CD4~+ CD25~(high) Treg peripheral blood in systemic lupus erythematosus patients[J].Journal of Bengbu Medical College,2011,36(11):1184-1186. |
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| Authors: | WANG Yuan-yuan CHEN Xiao-rong LIU Tong TANG Jie XIE Chang-hao |
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| Institution: | WANG Yuan-yuan1,2,CHEN Xiao-rong1,LIU Tong2,TANG Jie3,XIE Chang-hao4(1.Department of Histology and Embryology,Anhui Medical University,Hefei Anhui 230032,2.Department of Histology and Embryology,3.Key Laboratory of Infection and Immunity in Anhui,Bengbu Medical College,Bengbu Anhui 233004,4.Department of Rheumatology,The First Affiliated Hospital of Bengbu Medical College,China) |
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| Abstract: | Objective:To detect frequency of and programmed cell death-1(PD-1)expression of CD4+CD25high Treg peripheral blood of systemic lupus erythematosus(SLE) patients and to explore their roles in immune disorder of SLE.Methods:Flow cytometry(FCM) was used to determine the frequencies of peripheral blood CD4+CD25high Treg and CD4+CD25low T cells and the PD-1 expression on these cells in SLE patients and healthy normal controls.Results:The frequency of CD4+CD25high Treg among CD4+ Treg in peripheral blood of SLE p... |
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| Keywords: | lupus erythematosus systemic regulatory T cell programmed death-1 |
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