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| 瘦素受体基因Gln223Arg多态性与2型糖尿病的关系 | |
| 引用本文： | 张阳丹,李革,张名均,滕小春,陈春全,唐晓君.瘦素受体基因Gln223Arg多态性与2型糖尿病的关系[J].第三军医大学学报,2011,0(18):1932-1934. |
| 作者姓名： | 张阳丹 李革 张名均 滕小春 陈春全 唐晓君 |
| 作者单位： | 1. 重庆医科大学公共卫生学院流行病学教研室,重庆,400016 2. 重庆市九龙坡区第一人民医院检验科,重庆,400050 3. 重钢总医院：老年科,重庆,400081 4. 重钢总医院：药剂科,重庆,400081 |
| 基金项目： | 重庆市教委自然科学基金(KJ070313)~~ |
| 摘 要： | 目的 研究瘦素受体基因Gln223 Arg多态性与2型糖尿病的关系。方法采用病例对照研究方法，随机抽取重庆市2所医院的糖尿病门诊和住院初诊患者及其他疾病和门诊健康体检者共336例，其中病例组（糖尿病患者）172例，对照组（非糖尿病者）164例，调查其糖尿病危险因素，用聚合酶链反应-限制性片段长度多态性(PCR-RFLP... |
| 关 键 词： | 瘦素受体基因 Gln223Arg 2型糖尿病 |
Correlation between polymorphism of leptin receptor gene GIn223Arg and type 2 diabetes mellitus |
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| Zhang Yangdan,Li Ge,Zhang Mingjun,Teng Xiaochun,Chen Chunquan,Tang Xiaojun.Correlation between polymorphism of leptin receptor gene GIn223Arg and type 2 diabetes mellitus[J].Acta Academiae Medicinae Militaris Tertiae,2011,0(18):1932-1934. | |
| Authors: | Zhang Yangdan Li Ge Zhang Mingjun Teng Xiaochun Chen Chunquan Tang Xiaojun |
| Institution: | Zhang Yangdan1,Li Ge1,Zhang Mingjun2,Teng Xiaochun3,Chen Chunquan4,Tang Xiaojun1(1 College of Health Public,Chongqing Medical University,Chongqing,400016,2 First People's Hospital of Chongqing Jiulongpo District,400050,3 Department of Genriatrics,4Department of Pharmacy,General Hospital of Chongqing Steel and Iron Group,400081,China) |
| Abstract: | Objective To study the correlation between polymorphism of leptin receptor(LEPR) gene Gln223Arg and type 2 diabetes mellitus(DM).Methods Three hundred and thirty-six patients with DM or other diseases,randomly sampled from 2 two hospitals in Chongqing,were divided into DM group(n=172) and control group(n=164).Risk factors for DM were investigated with case-control method.Polymorphism of LEPR gene Gln223Arg was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and its r... |
| Keywords: | leptin receptor gene Gln223Arg diabetes mellitus |
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