| 顺铂体内注射对子代豚鼠耳蜗毛细胞的影响 |
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| 引用本文： | 郝帅,闫艾慧,姜学钧. 顺铂体内注射对子代豚鼠耳蜗毛细胞的影响[J]. 大连医科大学学报, 2011, 33(5): 434-436+440 |
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| 作者姓名： | 郝帅 闫艾慧 姜学钧 |
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| 作者单位： | 中国医科大学第一临床医院耳鼻咽喉科,辽宁沈阳,110001 |
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| 摘 要： | [目的]了解孕晚期顺铂暴露是否会诱导子代豚鼠耳蜗毛细胞损伤.[方法]将孕晚期豚鼠12只随机分为两组,在孕50 d至56 d,顺铂组经腹膜腔注射顺铂1,5mg/kg·d,对照组注射生理盐水1.5 mg/kg·d.出生后14d,应用原位末端转移酶标记技术(TUNEL)和Caspase-3免疫组化染色检测毛细胞凋亡情况.[结...
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| 关 键 词： | 毛细胞 凋亡 顺铂 |
Effect of cisplatin-injected on cochlear hair ceus in newborn guinea pigs |
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| HAO Shuai,YAN Ai-hui and JIANG Xue-jun. Effect of cisplatin-injected on cochlear hair ceus in newborn guinea pigs[J]. Journal of Dalian Medical University, 2011, 33(5): 434-436+440 |
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| Authors: | HAO Shuai YAN Ai-hui JIANG Xue-jun |
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| Affiliation: | HAO Shuai,YAN Ai-hui,JIANG Xue-jun (Department of Otolaryngology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China) |
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| Abstract: | [Objective] To evaluate the role of pregnant cisplatin exposure in inducing apoptosis on the development of cochlear in newborn guinea pigs.[ Methods] On gestational day 50 to 56,pregnant guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin and normal saline once a day,respectively.On postnatal day 14,the temporal bones of guinea pig pups were removed,immunohistochemistry was used for detecting the expression of caspase-3 and TUNEL method for hair cell apoptosis. [Results] Apopto... |
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| Keywords: | hair cell apoptosis pregnant cisplatin exposure |
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