| 胸腺五肽及其聚乙二醇衍生物的固相合成 |
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| 引用本文： | 韩月,王良友,尹志峰,高杨,赵红玲,吕逢春.胸腺五肽及其聚乙二醇衍生物的固相合成[J].承德医学院学报,2011,28(4):351-353. |
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| 作者姓名： | 韩月 王良友 尹志峰 高杨 赵红玲 吕逢春 |
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| 作者单位： | 承德医学院中药研究所,河北承德,067000 |
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| 摘 要： | 目的：Fomc法固相优化合成胸腺五肽（TP5）并对其进行聚乙二醇（PEG）修饰，以延长TP5在体内的半衰期。方法：采用固相合成技术合成PEG化TP5，高效液相色谱进行分析和纯化，氨基酸测序仪测序。结果：经鉴定，合成的TP5和PEG化TP5与理论值一致。结论：该方法操作简单、成本低，得到的产品纯度较高、易于纯化。
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| 关 键 词： | 胸腺五肽 聚乙二醇化 固相合成 |
SOLID PHASE SYNTHESIS OF THYMOPENTIN PENTAPEPTIDE AND PEGYLATED THYMOPETIDUM |
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| HAN Yue,WANG Liang-you,YIN Zhi-feng,et al.SOLID PHASE SYNTHESIS OF THYMOPENTIN PENTAPEPTIDE AND PEGYLATED THYMOPETIDUM[J].Journal of Chengde Medical College,2011,28(4):351-353. |
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| Authors: | HAN Yue WANG Liang-you YIN Zhi-feng |
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| Institution: | HAN Yue,WANG Liang-you,YIN Zhi-feng,et al(Institute of Chinese Mateia Medica,Chengde Medical College,Hebei Chengde 067000,China) |
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| Abstract: | Objective:To optimize the solid phase synthesis method of thymopentin pentapeptide(TP5) and synthesize pegylated TP5,so lengthen the half life period of TP5.Methods:Solid phase synthesis was used to synthesize TP5,high-performance liquid chromatography to analyze and purify,protein sequencer to detect the sequence of amino acid.Results:The TP5 and pegylation TP5 was in conformity with theoretical value.Conclusions:This craft is convenient and low cost,the purity of products is fairly high and the product is... |
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| Keywords: | Thymopentin pentapeptide Pegylation Solid phase synthesis |
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