2-β-(N-arylpiperazino) ethyl indandiones-1,3 and indandiols-1,3 |
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Authors: | I A Berzinya S K Germane Ya Ya Dregeris A K Aren |
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Institution: | (1) Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga |
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Abstract: | Conclusion By the action of N-arylpiperazines on the tosylates of 2- -hydroxyethyl-2-phenyl and 2-methylsubstituted indandiones-1,3 one obtains 2- -(N-arylpiperazino) ethyl derivatives of 2-substituted indandiones-1,3 which are reduced by sodium borane to the corresponding indandiol-1,3 derivatives. The arylpiperazino derivatives of 2-substituted indandiones-1,3 and indandiols-1,3 have neurotropic properties. A certain association between structure, toxicity, and pharmacological action of these compounds was noted.Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 25–29, October, 1968. |
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