不同氧疗方式对兔海水淹溺肺水肿的治疗作用

目的　观察不同氧疗方式对海水淹溺肺水肿 (PE -SWD)的治疗作用。方法　实验动物随机分为正常对照组、海水淹溺组、高压氧 (HBO)治疗组、机械通气 (MV)组。在不同时间点观察动脉血气分析、生命体征、肺损伤指标 ,并进行病理学检查和观察存活时间。结果　两种氧疗方式治疗后PaO2 、SaO2 较海水淹溺组有明显改善 (P <0 0 1) ,异常的生命体征得到一定程度纠正 ,肺损伤程度减轻。治疗组动物存活时间明显延长 ,且机械通气组优于高压氧组。结论　高压氧和机械通气治疗可明显控制PE -SWD时的低氧血症 ,并减轻肺损伤程度

Therapeutic effect of various oxygenation therapy on pulmonary edema after seawater drowning in rabbits

Objective To observe the therapeutic effect of hyperbaric oxygenation(HBO)and mechanical ventilation(MV)on pulmonary edema after seawater drowning(PE-SWD)in rabbits.Methods The rabbits were randomly divided into the control group,the PE-SWD group,the HBO therapy group and the MV group.Blood gas analysis,vital signs and lung injury status were monitored at various time points.After 3-hour therapy,7 rabbits of each group were killed for pathology.The others went on surviving and were observed till death.Results PaO 2 and SaO 2 were significantly improved after HBO therapy and MV therapy in PE-SWD rabbits ( P <0 01).The abnormality of vital signs was ameliorated.The degree of lung injury relieved.The rabbits in MV group and HBO group had longer survival time than those in PE-SWD group.The ones in MV group had the longest survival time.Conclusions Our study showed that HBO therapy and MV significantly improved hypoxemia of PE-SWD in rabbits,and relieved the degree of lung injury to some extent.