186例抗生素相关性腹泻的临床研究

目的探讨抗生素相关性腹泻的临床特点及治疗方法及预后。方法回顾性分析2006年3月～2011年3月入院治疗的186例抗生素相关性腹泻患者的发病时间、易感因素、抗生素使用情况以及治疗方法和疾病转归。结果有83．9％的患者抗生素使用时间超过1周，抗生素联合使用者占85．5％。抗生素使用时间越长、联合使用抗生素，其腹泻感染率均较高。大便菌群主要以革兰阳性菌为主。结论合理使用抗生素是预防抗生素相关性腹泻的关键，应引起广泛重视。

Clinical Investigation of 186 Patients with Antibiotic-associated Diarrhea

Objective To investigate the clinical characteristics and therapy methods of antibiotic-associated diarrhea （ AAD ）. Methods The disease time, risk factors, antibiotics＇ application, therapy methods and prognosis of 186 cases with AAD were retrospectively analyzed. Results The ones utilized antibiotics more than 1 week was 83.9% and the ones utilized multiple antibiotics was 85.5%. The longer the antibiotics use, the higher the inci＇dence rate of diarrhea. Fecal flora was mainly Gram-positive bacteria. Conclusion Rational use of antibiotics is the key to prevent antibiotic-associated diarrhea, which should be paid wide attention.