牙周炎与类风湿关节炎的相关性研究

目的　研究类风湿关节炎(RA)患者的牙周状况,初步探讨牙周炎与RA的关系。方法　选择70例RA患者为RA组,70例未患RA的健康人为对照组,两组在年龄及性别分布互相匹配。对RA组与对照组进行牙周状况检查,同时对RA组行类风湿病学检查,比较RA组和对照组间牙周状况的异同,并就RA组患者牙周状况与类风湿病学检查指标之间的关系进行分析。结果　RA组牙周炎患病率高于对照组(P<0·01),缺失牙数和探诊出血阳性率与对照组无统计学差异(P>0·05)。RA组牙周炎指数为5或6的牙数多于对照组(P<0·05),说明RA组患有中、重度牙周炎的牙数多于对照组。RA组中、重度牙槽骨丧失者,其晨僵时间、红细胞沉降率和C反应蛋白水平均高于无或轻度牙槽骨丧失者。结论　RA患者比正常人群更易罹患牙周炎,并以中、重度牙周炎较常见。

Relationship between Periodontal Disease and Rheumatoid Arthritis

Objective To study a population of rheumatoid arthritis patients and determine the extent of periodontal disease in these patients,in order to investigate the relationship between periodontal disease and rheumatoid arthritis.Methods The experimental group was composed of 70 patients with rheumatoid arthritis and the control group consisted of 70 age-and gender-matched individuals without rheumatoid arthritis.The relationship between periodontal status in rheumatoid arthritis and control groups as well as the relationship between periodontal status and rheumatological findings in patients were analyzed.Results The percentage of periodontal disease was statistically significant between experimental and control group(P<0.01).The difference of average number of missing teeth and bleeding on probing in the experimental group and control group were not statistically significant(P>0.05).There were more number of periodontal disease index 5 or 6 in experimental group than in control group(P<0.05).Rheumatoid arthritis patients with moderate to severe bone loss had deeper degree of morning stiffness,erythrocyte sedimentation rate levels and serum C-reactive protein levels than patients with no or mild bone loss.Conclusion Individuals with rheumatoid arthritis are more likely to experience periodontal disease compares to healthy subjects.They are also very likely to suffer from moderate to severe periodontitis.