2型糖尿病合并心血管疾病患者心率变异性分析

目的：研究糖尿病合并心血管疾病对心率变异性（HRV）的影响。方法：对44例糖尿病合并高血压、冠心病及48例单纯糖尿病患进行24小时心率变异时时域分析，同时与年龄、性别相当的62例正常人HRV资料进行比较。结果：（1）糖尿病患各项时域分析指标均较正常组降低（P＜0．05－＜0．01）；（2）与单纯糖尿病患比较，有心血管合并症的糖尿病患HRV参数中SDNN、SDANN、SDNN－index、rMSSD明显降低（P＜0．05－＜0．01）；（3）昼夜资料分析显示与正常组比较糖尿病患白天mR-R升高（P＜0．05），SDNN、rMSSD、PNN50显下降（P＜0．05－＜0．01），夜间各指标均明显降低（P＜0．05－＜0．01），合并高血压、冠心病的患除SDANN、PNN50外各指标下降更加显。提示糖尿病患的HRV分析有助于预测心脏事件的发生。

Analysis of the variability of circadian heart-rate in patients with type 2 diabetes combining with cardiovascular diseases

Objective: To study the impact on heart-rate variability (HRV) of patients with diabetes combining with cardiovascular diseases (DCD). Methods: The time index of 24 h HRV was analyzed in 44 cases of patients with diabetes combining with cardiovascular disease and 48 cases of patients with simple diabetes. Meanwhile. 62 healthy persons with correspondent age and sex were used for control group. Results: (1) The index of each time of patients with diabetes was lower (P<0. 05~<0. 01) than those of normal group) (2) Compared with patients with simple diabetes, SDNN, SDANN, SDNN-index.RMSSD in HRV parameter of DCD patients were significantly low(P<0. 05 ~<0. 01) j(3)The analysis of circadian data showed that night/day SDNN. rMSSD,PNN50 of patients with diabetes were significantly low (P<0. 05-<0. 01) than those of normal group, its change was more significant (P<0. 05-<0. 01) in DCD patients. Conclusion: HRV of patients with diabetes is abnormal. The abnormal degree is directly proportional to the severity of patients' condition. The abnormality of DCD patients is more significant.