Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
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Authors: | Namrata Singh Payal Bhardwaj Ravinder M Pandey Anoop Saraya |
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Institution: | 1. Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, 110 029, India 2. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110 029, India
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Abstract: | Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male?=?86) patients with CP, grouped as those with diabetes (case; n?=?23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean SD] age 36.4 9.7] vs. 29.3 10.0] years; p?=?0.032), had longer duration of CP 4 (0.3?C21) vs. 3 (0.3?C24) years; p?=?0.07), and had a lower TAC (269.8 92.4] vs. 355.5 128.6] ??moles Fe+2 liberated; p?=?0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 ??moles Fe+2 liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. |
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