5851例孕产妇感染性血清标志物检测及临床意义

目的了解孕产妇乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、梅毒及人类免疫缺陷病毒(HIV)的感染情况,探讨孕产妇感染性血清标志物检测的临床意义。方法对2005～2009年该院门诊和住院的5851例孕产妇进行产前乙型肝炎标志物(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc)、人类免疫缺陷病毒(Ⅰ型、Ⅱ型)抗体(抗-HIV1/2)、丙型肝炎抗体(抗-HCV)、梅毒螺旋体抗体梅毒螺旋体乳胶凝集试验(TPPA)]检测。结果 5851例孕产妇中,HBsAg和抗-HCV阳性率分别为10.56%和0.60%,5年间HBsAg和抗-HCV阳性率变化不明显,各年度阳性率相互比较差异无统计学意义;TPPA和抗-HIV阳性率分别为2.26%和0.03%。2009年分别与2008年、2007年、2006年和2005年TPPA阳性率比较差异有统计学意义(χ2=4.565,χ2=5.215,χ2=9.322,χ2=16.162,P0.05);2009年抗-HIV阳性率与前4年比较差异无统计学意义,但检测出2例阳性。结论泸州地区孕产妇以HBV感染为主,但有逐年下降的趋势;TPPA阳性率呈逐年上升趋势;HIV感染形势严峻。通过对孕产妇进行感染性血清标志物检测,是及早发现传染病和防止母婴垂直传播的有效防治措施之一,对减少新生儿传染病的发生,提高优生优育和人口素质尤为重要。

Infectious serum markers examination and its clinical significance in 5 851 pregnant women

Objective To understand the infections status of hepatitis B virus（HBV）,hepatitis C virus（HCV）,syphilis and human immunodeficiency virus（HIV）,and to explore the clinical significance of infectious serum markers.Methods During 2005-2009 in our hospital,5 851 outpatient and inpatient pregnant women received the detectiong of hepatitis B markers（HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc）,human immunodeficiency virus（Ⅰ type,Ⅱ type） antibody（anti-HIV1/2）,hepatitis C antibody（anti-HCV） and Treponema pallidum antibody（TPPA）.Results Among 5 851 pregnant women,HBsAg and anti-HCV positive rates were 10.56% and 0.60%.During 5 years,HBsAg and anti-HCV positive rate did not change significantly.The differeme of positive rate for each year had no statistical significance;TPPA and anti-HIV positive rates were 2.26% and 0.03%.In 2009,the TPPA positive rate had significant difference compared with 2008,2007,2006 and 2005（χ2=4.565,χ2=5.215,χ2=9.322,χ2=16.162,P0.05）;in 2009,anti-HIV-positive rate had no statistical difference compared with previouns 4 years,but positive detection was in two cases.Conclusion In this region,infection in pregnant women is mainly hepatitis B virus.But there is declining trend;TPPA positive rate show an upward trend year by year;HIV infection is very severe.Maternal infections serum markers detection is for the early detection of infectious diseases and the prevention of mother to child vertical transmission which is perticular impartant,to reduce the incidence of neonatal infectious diseases,improve the prenatal and postnatal care and the quality of the population.