棕色脂肪组织与肥胖症药物治疗的新靶点

肥胖症与许多代谢性疾病密切相关，而目前尚无治疗肥胖症的理想药物。棕色脂肪组织作为产热器官，可分解代谢脂肪，因而成为治疗肥胖症的重要靶组织。简述棕色脂肪组织的结构及作用，详细介绍了基于棕色脂肪组织治疗肥胖的药物作用靶点，其中具有代表性的有过氧化物酶体增殖物激活受体Y辅激活因子1a、锌指蛋白PRDM16和胎盘特异性蛋白8等，并对利用这些靶点治疗肥胖症的研究进行了综述。

Brown Adipose Tissue and New Targets for Obesity Treatment

Obesity is a disease closely related to many metabolic diseases. Up to now, however, there is still no ideal drug for the treatment of obesity. Brown adipose tissue （BAT）, as a key thermogenic organ through the catabolism of triacylglyeerine, has become an important target for the treatment of obesity. In this article, features of BAT and its function are briefly described. Drug targets which are based on BAT for obesity treatment such as peroxisome proliferator-aetivated receptor gamma coactivator-la（PGC-1a）, zinc-finger protein PRDM16, and placenta specific 8 （Plac8） are introduced in detail. And the research on the treatment of obesity with these targets is also reviewed.