The role of F-FDG PET/CT for evaluation of metastatic mediastinal lymph nodes in patients with lung squamous-cell carcinoma or adenocarcinoma |
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Authors: | Peiou Lu Yajuan Sun Yanqin Sun Lijuan Yu |
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Affiliation: | 1. Department of PET/CT, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China;2. Department of Radiological Diagnosis, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, Heilongjiang Province, China |
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Abstract: | ObjectivesTo evaluate the efficacy of 18F-FDG PET/CT in depicting metastatic mediastinal lymph nodes in patients with lung squamous-cell carcinoma (LSCC) or lung adenocarcinoma (LAC) in a tuberculosis-endemic country.MethodsThis study retrospectively reviewed patients with LSCC or LAC, who underwent preoperative 18F-FDG PET/CT to assess mediastinal lymph node metastasis. Patients with the short-axis of mediastinal lymph node ≤ 15 mm were included. PET/CT interpretation was analyzed in two ways. Firstly, with CT for anatomical localization, lymph nodes showing greater 18F-FDG uptake than vessel pool on PET were regarded malignant. Secondly, lymph nodes with positive uptake on PET were considered malignant, only when nodes had neither calcification nor higher attenuation than vessel pool on CT.ResultsOne hundred and sixteen LSCCs and 234 LACs were evaluated. With CT for anatomical localization, the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of PET were 78.6%, 45.5%, 53.4%, 31.4% and 87.0% in LSCC group, and 61.8%, 66.3%, 65.0%, 42.9% and 80.9% in LAC group. PET showed higher specificity and accuracy in LAC group compared with LSCC group (p = 0.001 and p = 0.038, respectively). Considering calcification or high attenuation on CT, the sensitivity, specificity, accuracy, PPV and NPV of PET/CT were 71.4%, 67.0%, 68.1%, 40.8% and 88.1% in LSCC group, and 54.4%, 86.1%, 76.9%, 61.7% and 82.2% in LAC group. Compared with PET, PET/CT possessed higher specificity and accuracy in LSCC group (p = 0.000 and p = 0.000, respectively), and higher specificity, accuracy and PPV in LAC group (p = 0.000, p = 0.000 and p = 0.022, respectively).Conclusions18F-FDG PET displays limited efficacy in assessing mediastinal lymph node metastasis with the short-axis diameter <15 mm in LSCC and LAC groups and higher false-positivity in LSCC group. The specificity and accuracy in LSCC and LAC groups are enhanced by interpreting attenuation characteristic on CT. |
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Keywords: | Positron emission tomography/computed tomography Lung squamous-cell carcinoma Lung adenocarcinoma Mediastinal lymph node metastasis |
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