Genetic variation in TNFA predicts protection from severe bacterial infections in patients with end-stage liver disease awaiting liver transplantation |
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| Authors: | Renata Senkerikova Emmeloes de Mare-Bredemeijer Sona Frankova Dave Roelen Thijmen Visseren Pavel Trunecka Julius Spicak Herold Metselaar Milan Jirsa Jaap Kwekkeboom Jan Sperl |
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| Affiliation: | 1 Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;2 Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;3 Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre, Rotterdam, The Netherlands;4 Department of Immunohematology and Blood Transfusion, University Medical Centre, Leiden, The Netherlands |
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| Abstract: | |
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| Keywords: | SBI, severe bacterial infections ESLD, end-stage liver disease OLT, orthotopic liver transplantation TLR, toll-like receptors TLR4, toll-like receptor 4 LPS, lipopolysaccharide SNP, single nucleotide polymorphism TNF-α, tumour necrosis factor-alpha IL-1β, interleukin-1 beta TNFA, tumour necrosis factor alpha IL1B, interleukin 1 beta IL1RN, interleukin 1 receptor antagonist VNTR, variable number of tandem repeats IL-1RA, interleukin-1 receptor antagonist SBP, spontaneous bacterial peritonitis EASL, European Association for the Study of the Liver CRP, C-reactive protein PCR, polymerase chain reaction HWE, Hardy-Weinberg equilibrium CV, coefficient variability OR, odds ratio CI, Confidence Interval MELD, model for end-stage liver disease |
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