首页 | 本学科首页   官方微博 | 高级检索  
     


Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells
Authors:Kengo Tomita  Toshiaki Teratani  Takahiro Suzuki  Motonori Shimizu  Hirokazu Sato  Kazuyuki Narimatsu  Shingo Usui  Hirotaka Furuhashi  Akifumi Kimura  Kiyoshi Nishiyama  Tadashi Maejima  Yoshikiyo Okada  Chie Kurihara  Katsuyoshi Shimamura  Hirotoshi Ebinuma  Hidetsugu Saito  Hirokazu Yokoyama  Chikako Watanabe  Shunsuke Komoto  Shigeaki Nagao  Kazuo Sugiyama  Suefumi Aosasa  Kazuo Hatsuse  Junji Yamamoto  Toshifumi Hibi  Soichiro Miura  Ryota Hokari  Takanori Kanai
Affiliation:1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan;2 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;3 Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan;4 Graduate School of Pharmaceutical Sciences, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan;5 Health Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Abstract:
Keywords:HSC, hepatic stellate cell   FC, free cholesterol   TLR4, Toll-like receptor 4   Bambi, bone morphogenetic protein and activin membrane-bound inhibitor   TGF, transforming growth factor   CE, cholesterol ester   ACAT, acyl-coenzyme A:cholesterol acyltransferase   MβCD, methyl-β-cyclodextrin   LPS, lipopolysaccharide   CCl4, carbon tetrachloride   BDL, bile duct ligation   ALT, alanine aminotransferase   HE, hematoxylin-eosin   SMA, smooth muscle actin   TUNEL, terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling   PCR, polymerase chain reaction   TNF, tumor necrosis factor   VCAM-1, vascular cell adhesion molecule-1   ICAM-1, intercellular adhesion molecule-1   MCP-1, monocyte chemoattractant protein-1
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号