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HLA-B27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope
Authors:Katja Nitschke  Alejandro Barriga  Julia Schmidt  Jörg Timm  Sergei Viazov  Thomas Kuntzen  Arthur Y Kim  Georg M Lauer  Todd M Allen  Silvana Gaudieri  Andri Rauch  Christian M Lange  Christoph Sarrazin  Thomas Eiermann  John Sidney  Alessandro Sette  Robert Thimme  Daniel López  Christoph Neumann-Haefelin
Institution:1 Department of Medicine II, University of Freiburg, Freiburg, Germany;2 Faculty of Biology, University of Freiburg, Freiburg, Germany;3 Instituto de Salud Carlos III, Majadahonda, Madrid, Spain;4 Institute of Virology, University Hospital, University of Duisburg-Essen, Essen, Germany;5 Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, USA;6 Division of Infectious Diseases, MGH, Boston, MA, USA;7 School of Anatomy, Physiology and Human Biology, University of Western Australia, Perth, Australia;8 Institute of Immunology and Infectious Disease, Murdoch University, Perth, Western Australia, Australia;9 Department of Infectious Diseases, Bern University Hospital and University of Bern, Switzerland;10 Department of Medicine I, J.W. Goethe University Hospital, Frankfurt, Germany;11 Transfusion Medicine, HLA-Laboratory, University Hospital Hamburg-Eppendorf, Hamburg, Germany;12 La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Abstract:
Keywords:HLA  human leukocyte antigen  HCV  hepatitis C virus  NS5B  non-structural protein 5B  PBMC  peripheral blood mononuclear cell  EBV  Epstein Barr virus  B-LCL  B-lymphoblastoid cell lines  IFN-γ  interferon-gamma
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