Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice

Authors:	Bakytzhan Bakhautdin Dola Das Palash Mandal Sanjoy Roychowdhury Jazmine Danner Katelyn Bush Katherine Pollard James W. Kaspar Wei Li Robert G. Salomon Megan R. McMullen Laura E. Nagy

Affiliation:	¹ Center for Liver Disease Research, Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States;² Department of Chemistry, Case Western Reserve University, Cleveland, OH, United States;³ Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, United States

Abstract:

Keywords:	ALD, alcoholic liver disease AST, aspartate amino transferase CK18, cytokeratin 18 CO, carbon monoxide CoPP, cobalt protoporphyrin CORM, CO-releasing molecule CYP2E1, cytochrome P450 2E1 EtOH, ethanol FADD, Fas-associated protein with death domain HO-1, heme oxygenase-1 iCORM-A1, inactive CORM-A1 IL-6, interleukin 6 iso[4]LGE₂, iso-levuglandin LPS, lipopolysaccharide MCP-1, monocyte chemoattractant protein-1 MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide PAGE, polyacrylamide electrophoresis RIP1, receptor interacting kinase 1 RIP3, receptor interacting kinase 3 SDS, sodium dodecyl sulphate SEM, standard error of the mean TLR-4, toll-like receptor 4 TNF-α, tumour necrosis factor α
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