Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions |
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Authors: | Beierlein Wolfram Scheule Albertus M Dietrich Wulf Ziemer Gerhard |
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Affiliation: | a Department of Thoracic, Cardiac, and Vascular Surgery, Tübingen University Hospital, Tübingen, Germany b Department of Anesthesiology, German Heart Center Munich, Munich, Germany |
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Abstract: | Since its clinical introduction, the anaphylactic potential of aprotinin has been a major concern. World wide, its use is expanding so there is an increased chance that patients have reexposure from various sources. The risk of anaphylaxis is approximately 2.8% in reexposed patients. From 1963 to 2003, 124 cases of aprotinin-induced anaphylaxis were reported in 61 publications. Eleven patients died. The reexposure interval was less than 3 months in 72% (38 of 53 patients). This review looks at the profile of patients at risk so preventive measures may be taken. Past and future exposures have to be taken into account before any aprotinin administration. |
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Keywords: | 16 |
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