超敏C-反应蛋白水平与心脑血管病的关系分析

目的：探讨心脑血管病患者血清超敏C-反应蛋白（hs—CRP）水平及临床意义。方法：选择住院治疗的脑卒中患者176例为脑卒中组，其中脑梗塞133例，脑溢血43例，又根据神经功能缺损评分分为1组（轻度，67例），2组（中度，67例），3组（重度，42例）；冠心病患者104例为冠心病组，其中，稳定型心绞痛（SAP，34例），不稳定型心绞痛（UAP，34例），急性心肌梗塞（AMI，36例）；正常人64例为正常对照组。采用免疫比浊法检测hs—CRP水平。结果：脑卒中组及冠心病组的血清hs—CRP水平显著高于正常对照组（P均〈0．01）。脑卒中组神经功能缺损越重，血清hs—CRP水平越高，组间比较差异显著（P〈0．05～〈0．01）。冠心病组AMI患者的血清hs—CRP水平较SAP、UAP显著升高（P〈0．01，〈0．05）。绪论：血清hs—CRP参与了心脑血管病后的炎症反应，且与病变严重程度有关。

Correlation among the levels of serum high-sensitivity C-reactive protein and coronary artery disease, cerebrovascular disease

Objective： To investigate the correlation among levels of serum high-sensitivity C--reactive protein （hs-- CRP） and coronary artery disease （CAD）, cerbrovascular disease. Methods： The study recruited 176 cases with stroke stroke group, in which 133 patients with acute cerebral infarction and 43 patients with cerebral hemorrhage; also dividedintogroupⅠ （NIHSS〈4, 67 cases）, Ⅱ （NIHSS4-15, 67 cases）, Ⅲ （NIHSS〉15, 42 cases）according NIHSS] and 104 CAD patients CAD group, in which 36 patients with acute myocardial infarction （AMI） and 34 patients with stable angina pectoris （SAP）, 34 patients with unstable angina （UAP）]; 64 healthy individuals regard as normal control group. The serum hs--CRP levels were measured with immunotrubidimetry （ITM）. Results： The levels of serum hs--CRP in both CAD and cerebrovascular disease were significant higher than that of normal control group （P〈0.01 all）. The hs--CRP of group Ⅲ was higher than that of group Ⅰ and Ⅱ（P〈0.05-〈0, 01） in stroke group. The hs--CRP level in AMI patients was higher than that of SAP and UAP （P〈0.05-〈0.01）. Conclusion： The elevated levels of hs--CRP is closely correlated with inflammatory reaction of coronary artery disease and eerebrovascular disease and its severity.