| 靶向哺乳动物雷帕霉素靶蛋白治疗卵巢癌的研究进展 |
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| 引用本文： | 陈华娇,黄 胜,牛培广,等.靶向哺乳动物雷帕霉素靶蛋白治疗卵巢癌的研究进展[J].海峡药学,2014(3):1-4. |
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| 作者姓名： | 陈华娇 黄 胜 牛培广 等 |
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| 作者单位： | [1]福建省妇幼保健院药剂科,福州350001 [2]福建医科大学药学院,福州350004 |
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| 基金项目： | 福建省自然科学基金资助项目（2012J01312） |
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| 摘 要： | 哺乳动物雷帕霉素靶蛋白（Mammalian target of rapamycin，mTOR）是调控细胞代谢、生长和增殖等重要生命活动的蛋白激酶，mTOR异常表达在卵巢癌发生发展中起重要作用，已成为卵巢癌治疗的有效靶点。mTOR抑制剂雷帕霉素及其同系物能够抑制卵巢癌细胞生长和血管生成，并同其他抗肿瘤药物有协同作用，靶向m-IOR的研究将为卵巢癌的临床治疗带来新希望。
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| 关 键 词： | mTOR抑制剂 卵巢癌 治疗 |
Research progress in ovarian cancer treatment by targeting mTOR |
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| CHEN Hua-jiao,HUANG Sheng,NIU Pei-guang,SHI Dao-hua.Research progress in ovarian cancer treatment by targeting mTOR[J].Strait Pharmaceutical Journal,2014(3):1-4. |
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| Authors: | CHEN Hua-jiao HUANG Sheng NIU Pei-guang SHI Dao-hua |
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| Institution: | 1. Department of Pharmacology, Fu jian Provincial Maternity And Children Health Hospital, Fuzhou,35000], Chinas2. College of pharmacy, Fujian Medical University, Fuzhou 3.50004,China) |
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| Abstract: | Mammalian target of rapamycin （ mTOR） is a protein kinase that regulates cell metabolism ,growth, proliferation and other important biological activities.mTOR plays an important role in the development of ovarian cancer and has became an effective target for ovarian cancer therapy.Rapamycin,an mTOR inhibitor,and its deriva-tives can inhibit the growth and angiogenesis of ovarian cancer.Rapalogues exhibit synergism effect on ovarian cancer treatment when combined with other anticancer drugs.The research on mTOR will bring new hope for clinical treat-ment of ovarian cancer. |
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| Keywords: | mTOR mTOR mTOR inhibitor ovarian cancer treatment |
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