结直肠癌根治术后复发转移的相关因素分析

目的:探讨结直肠癌术后复发转移的相关临床病理因素,以提高结直肠癌根治疗效。方法:应用单因素和多因素分析方法,回顾性分析我院1995～2003年455例结直肠癌根治术后病例的临床病理资料。结果:单因素分析显示,肿瘤部位、肿瘤大小、Dukes’分期、淋巴结转移和组织学类型与结直肠癌术后复发转移有关。多因素分析显示,肿瘤部位、Dukes’分期是影响结直肠癌术后复发转移的重要因素。分别行远处转移和局部复发多因素分析显示,淋巴结转移、肿瘤部位与局部复发密切相关,而Dukes’分期与远处转移相关。结论:肿瘤部位、Dukes’分期是结直肠癌术后复发转移的重要危险因素。Dukes’分期是术后远处转移的重要因素,肿瘤位于直肠伴淋巴结转移者术后局部复发的风险较大。

Multiple factors analysis of recurrence and metastasis following radical surgery for colorectal cancer

Objective:This study was to investigate the clinicopathologic factors related to recurrence and metastasis following curative surgery for colorectal cancer,in order to improve the treatment effects.Method:The clinicopathologic factors and follow-up data of 455 cases of colorectal cancers after surgical treatment from 1995 to 2003 were retrospectively analyzed by univariate and multivariate methods.Results:Univariate analysis showed that tumor location,tumor size,Dukes' stage,lymph node metastasis and histological differentiation were significantly associated with recurrence and metastasis.Multivariate analysis showed that tumor location and Dukes' stage were prognostic factors for recurrence and metastasis after operation.In separate analysis of distant metastasis and local recurrence with multivariate method,lymph node metastasis and tumor location were closely related to local recurrence.Dukes'stage was related to distant metastasis.Conclusions:Tumor location and Dukes' stage are important risk factors for recurrence and metastasis after radical surgery for the patients with colorectal carcinoma.Dukes' stage is an important prognostic factor for distant metastasis.The patients with rectal cancer associated with lymph node metastasis should be considered to have additional risks for local recurrence.