脑血管病患者高Hcy血症与叶酸和维生素B12的相关性研究

目的探讨脑血管病患者高同型半胱氨酸(Hcy)血症与叶酸、维生素B12之间的相关性。方法分别检测脑血管病患者和健康对照者血清Hcy、叶酸和维生素B12水平。结果脑血管病组血清Hcy水平显著高于对照组(P<0.01),其中脑梗塞组的血清Hcy水平明显高于脑出血组(P<0.01)。与之相反,脑血管病组的血清叶酸和维生素B12水平明显低于对照组(P<0.01)。相关分析结果显示,脑血管病组的血清叶酸和维生素B12水平与Hcy水平呈负相关(r1=-0.80,r2=-0.83)。结论高Hcy血症与叶酸、维生素B12之间存在负反馈的调节机制可能正是导致脑血管病发生的关键因素。

Study on the relationship between Hyperhomocysteinemia and folate,vitamin B12 in cerebrovascular disease patients

Objective To investigate the relationship between Hyperhomocysteinemia and folate,vitamin B12in cerebrovascular disease patients.Methods Serum Hcy level was measured by enzyme method.Auto chemiluminescence immunoassay（CLIA） was applied for detecting serum folate and vitamin B12 levels in all groups.Results Serum Hcy levels in cerebrovascular disease group were significantly higher than those in control group（P〈0.01）.Moreover,serum Hcy levels in CI group were obviously higher than those in CH group（P〈0.01）.In contrast,serum folate and VitB12 levels in cerebrovascular diseases group were obviously lower than those in control group（P〈0.01）.Meanwhile,correlation analysis results showed that serum folate and VitB12 levels were negatively correlated with serum Hcy levels in cerebrovascular diseases group（r1=-0.80,r2=-0.83）.Conclusion The negative regulation mechanism between Hyperhomocysteinemia and folate,vitamin B12 is a key factor resulting in occurrence of cerebrovascular diseases.