Modulation of Immunological Abnormalities of Growth Hormone-Deficient Children by Growth Hormone Treatment |
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| Authors: | Mikio Matsuura MD Yumio Kikkawa MD Teruo Kitagawa MD Shingo Tanaka MD |
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| Institution: | Department of Pediatrics, Nihon University School of Medicine, Tokyo;Bio Medical Laboratories, Tokyo |
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| Abstract: | We studied the immunomodulatory role of growth hormone (GH) treatment in GH-deficient children. CH potentiated natural killer (NK)cell activity and the PHA and Con-A lymphocytoproliferative response. Two-color fluorescence using monoclonal antibodies (CLM, 2H4, CD8 and CD11) showed a moderate reduction of the helper T cells and NK cells, but no changes of suppressor T cells or cytotoxic T-cells during GH therapy. Cancer and slow viral infection in GH-deficient children have been watched for carefully before and after GH therapy. |
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