A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405 |
| |
Authors: | Fujita Yoko Kizuka Masaaki Funabashi Masanori Ogawa Yasumasa Ishikawa Tomio Nonaka Koichi Takatsu Toshio |
| |
Institution: | Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co. Ltd, Tokyo, Japan. fujita.yoko.x8@daiichisankyo.co.jp |
| |
Abstract: | During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2' position. A-90289 A and B inhibited bacterial translocase I with IC(50) values of 36.5?ng?ml(-1) and 33.8?ng?ml(-1), respectively. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|