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Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia |
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| Authors: | Flávia Campos Lucena Eura Martins Lage Patrícia Gonçalves Teixeira Alexandre Simões Barbosa Rejane Diniz Bashir Lwaleed |
| Institution: | 1. Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil;2. Department of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil;3. Department of Epidemiology, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, Brazil;4. Department of Urology, University of Soutampton, Southampton, UK |
| Abstract: | Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–40 weeks of gestation. Results: D-Di was lower at 12–19 weeks and higher at 30–34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn’t differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12–19 and 30–34 weeks of gestation. |
| Keywords: | Preeclampsia D-dimer PAI-1 longitudinal study hypercoagulability |