Three new tetralol analogs from soil-derived fungus Myrothecium verrucaria with anti-inflammatory activity |
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| Authors: | Lu Liu Ming-Xu Tang Xia-Nan Sang Shao-Fei Chen Xiao-Jie Lu Yu-Bo Wang |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;3. School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China |
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| Abstract: | Three new tetralol analogs, myrochromanols A-C (1–3), together with 11 known trichothecenes (4–14), were isolated from a soil fungus Myrothecium verrucaria HL-P-1. The structures of the three new compounds were elucidated by extensive spectroscopic analysis including HRESIMS, NMR, and ECD calculation. All of the new compounds were tested for their anti-inflammatory activity and cytotoxicity. Compounds 1 and 3 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells with IC50 values of 26.04 and 25.80 μM, respectively. |
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| Keywords: | Tetralol analogs Myrothecium verrucaria anti-inflammation cytotoxicity |
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