A new labdane-type diterpenoid from Leonurus japonicus |
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Authors: | Min-Hong Jiang Yue Hu Lin Jiao Pan Dong Sheng Yin Zhi-Min Zhao |
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Affiliation: | 1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;2. Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China |
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Abstract: | Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2–10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell line (IC50 = 23.75 μM). |
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Keywords: | Labiatae Leonurus japonicus labdane-type diterpenoids cytotoxic activity |
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