Chemical constituents from the whole herb of Hemiphragma heterophyllum |
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| Authors: | Jia-Meng Dai Yan-Hong Li Xiao-Yun Pu Cui Yang Jing-Xian Sun Roger Ruan |
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| Affiliation: | Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University , Kunming 650500, China |
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| Abstract: | Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (?)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data. Further, the structure of compound 3 was unambiguously confirmed by single-crystal X-ray analysis. Some of those compounds showed moderate activity in the α-glucosidase inhibition assay.  | |
| Keywords: | Scrophulariaceae Hemiphragma heterophyllum sesquineolignans iridoids α-glucosidase inhibitory activity |
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