A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus |
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| Authors: | Cheng-Shi Jiang Yan-Qiong Guo Sheng Yin |
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| Affiliation: | 1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China;2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China |
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| Abstract: | Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 0.96 ± 0.04 μM. |
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| Keywords: | Chloranthaceae Chloranthus japonicus lindenane-type sesquiterpenoid rosmarylchloranthalactone E phosphodiesterase-4 |
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