Four new diarylheptanoids from Rhizoma Zingiberis |
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| Authors: | Wan-Hua Cui Ze-Zhi Li Yan Guo Mei-Ling Gao Yong-Xian Cheng |
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| Institution: | 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China;2. Guangdong Key Laboratory for Genome Stability &3. Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China |
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| Abstract: | Four new diarylheptanoids, (1S, 3R, 5R, 6R)-1, 5-epoxy-3, 6 dihydroxy-1-(4-hydroxy-3, 5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptane (1), (1R, 3R, 5S)-1, 5-epoxy-3-acetoxy-1-(4, 5-dihydroxy-3-methoxyphenyl)-7-(3, 4- hydroxyphenyl) heptane (2), (3R, 5S, 6R, 7S)-3, 6-epoxy-7-hydroxyl-1-(4-hydroxyphenyl)-7-(3-methoxy-4-hydroxyphenyl) heptane (3), (E)-3-keto-1-(3-methoxy-4-hydroxyphenyl)-7-(4, 5-dihydroxy-3-methoxyphenyl)-4- heptene (4), were isolated from Rhizoma Zingiberis, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-NMR and 2D-NMR). Compounds 1–4 exhibited no cytotoxicity against HepG2 cell lines. 
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| Keywords: | Zingiberaceae Rhizoma Zingiberis diarylheptanoids cytotoxicity |
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