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Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia |
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| Authors: | Chandrakala Nagarajappa Sheela Shikaripur Rangappa Ravishankar Suryanarayana |
| Affiliation: | 1. Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India;2. Department of Obstetrics and Gynecology, Sri Devaraj Urs Medical College, Kolar, India;3. Department of Community Medicine, Sri Devaraj Urs Medical College, Kolar, India |
| Abstract: | Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding.Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo Red Dot assay respectively.Results: Significant difference was observed in the levels of protein carbonyls (P = 0.002) and misfolded proteins (P = 0.001). Correlation between protein carbonyl and misfolded proteins levels was significant but weak (r = 0.3; P = 0.018).Conclusion: Urinary protein carbonyl level is elevated in preeclampsia but plays a minor role in proteins misfolding. |
| Keywords: | Preeclampsia protein carbonyl misfolded proteins |