|
|||||
|
|
Arm crank ergometry improves cardiovascular disease risk factors and community mobility independent of body composition in high motor complete spinal cord injury |
|
| Authors: | James J Bresnahan Gary J Farkas Jody L Clasey James W Yates David R Gater |
| Institution: | 1. Department of Medicine, Abington Hospital – Jefferson Health, Abington, Pennsylvania;2. Department of Physical Medicine and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;3. Department of Physical Medicine and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;4. Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky;5. Department of Physical Medicine and Rehabilitation, University of Kentucky, Lexington, Kentucky |
| Abstract: | Objective: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. Design: Longitudinal interventional study at an academic medical center. Methods: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24.5 ± 6.0) with high motor complete SCI (C7-T5) underwent ACE exercise training 30 minutes/day?×?3 days/week for 10 weeks at 70% VO2Peak. Outcome Measures: Primary outcome measures were pre- and post-intervention changes in markers of cardiovascular fitness (graded exercise testing (GXT): VO2, VO2Peak, respiratory quotient RQ], GXT time, peak power, and energy expenditure EE]) and community mobility (time to traverse a 100ft-5° ramp, and 12-minute WC propulsion test). Secondary outcome measures were changes in body composition and metabolic profiles (fasting and area under the curve for glucose and insulin, homeostasis model assessment HOMA] for %β-cell activity %β], %insulin sensitivity %S], and insulin resistance IR], and Matsuda Index ISIMatsuda]). Results: Resting VO2, relative VO2Peak, absolute VO2Peak, peak power, RQ, 12-minute WC propulsion, fasting insulin, fasting G:I ratio, HOMA-%S, and HOMA-IR all significantly improved following intervention (P < 0.05). There were no changes in body composition (P>0.05). Conclusions: Ten weeks of ACE at 70% VO2Peak in high motor complete SCI improves aerobic capacity, community mobility, and metabolic profiles independent of changes in body composition. |
| Keywords: | |