Sinulaspirolactam A,a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral Sinularia sp. |
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| Authors: | Wei Lai Sheng-Ying Qin Ge Zou Xiao-Jian Liao Guo-Dong Chen Hua Zhang |
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| Affiliation: | 1. Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China;2. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510632, China;3. College of Pharmacy, Jinan University, Guangzhou, 510632, China |
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| Abstract: | A novel valerenane sesquiterpenoid sinulaspirolactam A (1), together with five known compounds, was isolated from the soft coral Sinularia sp. Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 was the first example of valerenane sesquiterpenoid bearing an aza-spiro[4.5] ring moiety, the plausible biogenetic pathway of which was proposed. Cytotoxic activities of these compounds were also evaluated. |
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| Keywords: | Alcyoniidae Sinularia sp valerenane sesquiterpenoid cytotoxicity |
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