Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid |
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Authors: | Zhixiong CHEN Jiong YANG Qiong HUANG |
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Institution: | 1. Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China 2. Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China |
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Abstract: | Summary The correlation between the expression of COX-2 and p53 protein in basal cell carcinoma (BCC) of eyelid and apoptosis was
investigated. Specimens of BCC were collected from 40 cases (aged 28–68 y) at the Department of Pathology, Renmin Hospital
of Wuhan University, and Department of Pathology, Zhongnan Hospital of Wuhan University during from 1999 to 2006. Five specimens
of paracancerous tissues served as control group. Immunohistochemical staining was performed to detect the expression of COX-2
and p53 in the tissues. The average absorbance (A) and the average positive area rate of COX-2 and p53 protein were measured by image analysis. The positive area rate of COX-2
and p53 protein was analyzed by linear correlation analysis. It was found that COX-2 and p53 proteins were highly expressed
in BCC of eyelid, and weakly expressed in paracancerous tissues. Image analysis revealed that the expression of COX-2 and
p53 proteins in BCC of eyelid was significantly higher than that in paracancerous tissues (P<0.01). Spearman rank correlation analysis demonstrated a positive correlation between the expression of COX-2 and p53 (r=0.113, P=0.421). It was concluded that COX-2 can increase the expression of p53 protein, therefore suppressing apoptosis. |
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Keywords: | eyelid basal cell carcinoma COX-2 p53 protein |
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