上皮型钙黏蛋白在宫颈癌中的表达及其临床意义

目的 探讨上皮型钙黏蛋白（Ｅ－ｃａｄｈｅｒｉｎ,Ｅ－ＣＤ）在宫颈癌前病变及宫颈癌中的表达及其临床意义。方法 应用Ｓ－Ｐ免疫组化法和抗Ｅ－ＣＤ抗体观察６０例宫颈癌、１０例正常宫颈上皮组织和１２例宫颈上皮内瘤样病变（ＣＩＮ）中Ｅ－ＣＤ的表达。结果 正常宫颈上皮组织中Ｅ－ＣＤ１００％表达,ＣＩＮ中Ｅ－ＣＤ阳性率为６６．７％,而宫颈癌组织中Ｅ－ＣＤ阳性率仅为４６．７％。随着肿瘤病理分级的升高,Ｅ－ＣＤ表达下降,其Ⅰ、Ⅱ、Ⅲ级Ｅ－ＣＤ阳性率分别为７１．４％、４６．２％、和３０．０％（Ｐ〈０．０５）。Ｅ－ＣＤ表达在淋巴结转移组（２７．３％）明显低于无淋巴结转移组（７５．９％,Ｐ〈０．０５）。临床分期愈晚,Ｅ－ＣＤ表达愈低,Ⅰ～Ⅱ期和Ⅲ～Ⅳ期Ｅ－ＣＤ阳性率分别为６２．５％和１５．０％（Ｐ〈０．０５）。结论 随着宫颈癌的发生发

E-cadherin expression and its clinical significance in cervical cancer

Objective To study the clinical significance of E cadherin (E CD) expression in cervical cancer.Methods Specimens of 60 cervical cancer,10 normal cervical epithelia and 12 cervical intraepithelial neoplasia(CIN) were examined for E CD expression by immunohistochemical staining.Results E CD was expressed in all of 10 specimens of normal cervical epithelia.Positive staining was seen in 66.7% of CIN, 46.7% of cervical cancer. In cervical cancer,the frequency of abnormal E CD expression was correlated to pathologic grade,lymph node metastasis and clinical stage ( P <0.05).The higher the pathologic grade of tumor,the lower was the expression of E CD.Negative E CD expression was significantly more frequent in the advanced stage of cervical cancer with lymph node metastasis.Conclusion Decreased expression of E CD is a useful parameter of cervical malignancy.