全身调控一氧化氮水平对多发性关节炎大鼠颞下颌关节的影响

为了观察全身调控一氧化氮（ＮＯ）水平对多发性关节炎大鼠颞下颌关节（ＴＭＪ）的影响，探讨ＮＯ对关节炎症的作用机制，用福氏完全佐剂剂建立大鼠多发性关节炎模型；分组腹腔注射内源性ＮＯ抑制剂ＮＧ－ｎｉｔｒｉｏ－Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－ＮＮＡ）及生成剂Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－Ａｒｇ）；观察大鼠ＴＭＪ的组织病一学变化。结果表明用Ｌ－ＮＮＡ后ＴＭＪ的炎症反应和破坏程度显著减轻；而用Ｌ－Ａｒｇ后情况则相反，滑

EFFECTS OF GENERAL NITRIC OXIDE REGULATION ON TEMPOROMANDIBULAR JOINT IN RATS WITH POLYARTHRITIS

To probe into the action of nitric oxide (NO) on the pathogenesis of polyarthritis by observing the effects of general NO regulation on temporomandibular joint (TMJ), The animal model of polyarthritis was established by injecting Freund's complete adjuvant into rats. The endogenous NO inhibitory agent NG nitrio L arginine (L NNA) or the aggravating agent L arginine (L Arg) were injected into the abdominal cavities of different groups of polyarthritic rats seperately. And the histopathological changes of rats TMJ were observed. The results showed that the inflammation and the destruction of the TMJ tissues were abated obviously after taking L NNA; but the conditions of TMJ were exacerbated following the use of L Arg, such as worsening of the synovial cell proliferation, hemangiectasis, inflammatory exudation and destruction of articular cartilage. It was suggested that the general regulation of NO hads some definite effects on the arthritis in TMJ, and the inflammation and destruction of TMJ might markedly be eliminated by decreasing the level of NO properly at an early stage.