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| 慢性肾脏病肾组织炎症信号通路p38MAPK的 调节机制及中药的干预作用 | |
| 引用本文： | 赵青,万毅刚,王朝俊,魏晴雪,陈好利,孟宪杰,姚建. 慢性肾脏病肾组织炎症信号通路p38MAPK的 调节机制及中药的干预作用[J]. 中国中药杂志, 2012, 37(12): 1700-1704 |
| 作者姓名： | 赵青 万毅刚 王朝俊 魏晴雪 陈好利 孟宪杰 姚建 |
| 作者单位： | 1. 南京中医药大学中西医结合鼓楼临床医学院,江苏南京,210029 2. 南京大学医学院附属鼓楼医院中医科,江苏南京,210008 3. 昆山市中医院,江苏昆山,215300 4. Department of Molecular Signaling University of Yamanashi,Yamanashi, Japan 409-3898 |
| 基金项目： | 江苏省"六大人才高峰"项目(2010-WS-001) |
| 摘 要： | 肾组织的炎症反应及其相关的组织损伤(如肾小球硬化和肾间质纤维化)是导致慢性肾脏病(chronic kidneydisease,CKD)进展至终末期肾病的重要因素。其中,p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路能够调控多种核转录因子的表达和生物活性,还可以影响下游炎症介质的合成,并参与炎症细胞的活化,在肾脏疾病炎症损伤中发挥着重要的作用。某些单味中药及其提取物(如大黄素、黄连素)以及一些中药复方(如益肾活血汤)可以通过调节p38MAPK信号通路而影响肾组织内炎症反应,从而,减轻肾小球、肾间质炎症损伤。 |
| 关 键 词： | 慢性肾脏病 中药 p38丝裂原活化蛋白激酶 信号通路 |
| 收稿时间： | 2011-12-27 |
Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine |
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| ZHAO Qing,WAN Yigang,WANG Chaojun,WEI Qingxue,CHEN Haoli,MENG Xianjie and YAO Jian. Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine[J]. China Journal of Chinese Materia Medica, 2012, 37(12): 1700-1704 | |
| Authors: | ZHAO Qing WAN Yigang WANG Chaojun WEI Qingxue CHEN Haoli MENG Xianjie YAO Jian |
| Affiliation: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Department of Molecular Signaling University of Yamanashi, Yamanashi 409-3898, Japan |
| Abstract: | |
| Keywords: | chronic kidney disease traditional Chinese medicine p38 mitogen-activated protein kinase signaling pathway |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |