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| 慢性肾脏病肾组织炎症信号通路p38MAPK的 调节机制及中药的干预作用 | |
| 引用本文： | 赵青,万毅刚,王朝俊,魏晴雪,陈好利,孟宪杰,姚建.慢性肾脏病肾组织炎症信号通路p38MAPK的 调节机制及中药的干预作用[J].中国中药杂志,2012,37(12):1700-1704. |
| 作者姓名： | 赵青 万毅刚 王朝俊 魏晴雪 陈好利 孟宪杰 姚建 |
| 作者单位： | 1. 南京中医药大学中西医结合鼓楼临床医学院,江苏南京,210029 2. 南京大学医学院附属鼓楼医院中医科,江苏南京,210008 3. 昆山市中医院,江苏昆山,215300 4. Department of Molecular Signaling University of Yamanashi,Yamanashi, Japan 409-3898 |
| 基金项目： | 江苏省"六大人才高峰"项目(2010-WS-001) |
| 摘 要： | 肾组织的炎症反应及其相关的组织损伤(如肾小球硬化和肾间质纤维化)是导致慢性肾脏病(chronic kidneydisease,CKD)进展至终末期肾病的重要因素。其中,p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路能够调控多种核转录因子的表达和生物活性,还可以影响下游炎症介质的合成,并参与炎症细胞的活化,在肾脏疾病炎症损伤中发挥着重要的作用。某些单味中药及其提取物(如大黄素、黄连素)以及一些中药复方(如益肾活血汤)可以通过调节p38MAPK信号通路而影响肾组织内炎症反应,从而,减轻肾小球、肾间质炎症损伤。 |
| 关 键 词： | 慢性肾脏病 中药 p38丝裂原活化蛋白激酶 信号通路 |
| 收稿时间： | 2011/12/27 0:00:00 |
Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine |
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| ZHAO Qing,WAN Yigang,WANG Chaojun,WEI Qingxue,CHEN Haoli,MENG Xianjie and YAO Jian.Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine[J].China Journal of Chinese Materia Medica,2012,37(12):1700-1704. | |
| Authors: | ZHAO Qing WAN Yigang WANG Chaojun WEI Qingxue CHEN Haoli MENG Xianjie and YAO Jian |
| Institution: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China;Department of Molecular Signaling University of Yamanashi, Yamanashi 409-3898, Japan |
| Abstract: | |
| Keywords: | chronic kidney disease traditional Chinese medicine p38 mitogen-activated protein kinase signaling pathway |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |