| 丹参多组分渗透泵片在Beagle犬体内的药动学研究 |
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| 引用本文： | 周琳,刘宪英,郑金凤,吴清,杜守颖. 丹参多组分渗透泵片在Beagle犬体内的药动学研究[J]. 中国中药杂志, 2012, 37(12): 1761-1764 |
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| 作者姓名： | 周琳 刘宪英 郑金凤 吴清 杜守颖 |
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| 作者单位： | 北京中医药大学中药学院,北京,100102 |
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| 基金项目： | 国家自然科学基金项目(81073059);国家高技术研究发展计划(863)项目(2009AA043201);国家重点实验室开放基金项目(SKL2010Z0304);北京中医药大学自主课题(2011JYBZZ-XS039);北京中医药大学复方中药制药研究创新团队 |
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| 摘 要： | 目的:以丹参普通片为参比制剂,研究Beagle犬口服丹参多组分渗透泵片后药物在血浆中的浓度变化,评价丹参多组分渗透泵片的缓释行为。方法:采用HPLC测定,日本岛津ODS-SP色谱柱(4.6 mm×150 mm,5μm),流速1 mL.min-1,柱温30℃。丹参酮ⅡA和丹酚酸B的血浆样品分别以乙酸乙酯萃取和丙酮沉淀的方法除去蛋白,根据测定结果求算药代动力学参数。结果:2种极性不同的成分的方法学考察均符合要求,与丹参普通片相比,Beagle犬口服丹参多组分渗透泵片后,Cmax降低,Tmax延长。结论:与丹参普通片相比,丹参多组分渗透泵片具有良好的缓释效果。
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| 关 键 词： | 丹参 中药多组分渗透泵片 药代动力学 生物半衰期 Beagle犬 |
| 收稿时间： | 2011-12-05 |
Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs |
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| ZHOU Lin,LIU Xianying,ZHENG Jinfeng,WU Qing and DU Shouying. Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs[J]. China Journal of Chinese Materia Medica, 2012, 37(12): 1761-1764 |
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| Authors: | ZHOU Lin LIU Xianying ZHENG Jinfeng WU Qing DU Shouying |
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| Affiliation: | Beijing University of Chinese Medicine, Beijing 100102, China;Beijing University of Chinese Medicine, Beijing 100102, China;Beijing University of Chinese Medicine, Beijing 100102, China;Beijing University of Chinese Medicine, Beijing 100102, China;Beijing University of Chinese Medicine, Beijing 100102, China |
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| Abstract: | Objective: To study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation,in order to assess the sustained release of Danshen multi-component osmotic pump tablets.Method: HPLC was adopted for determination,with Shimadzu′s ODS-SP column(4.6 mm×150 mm,5 μm),flow rate of 1 mL·min-1,and column temperature of 30 ℃.Protein in plasma samples of tanshinone ⅡA and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively.Their pharmacokinetic parameters were calculated based on determination results.Result: The methodology study on the two constituents with different polarity showed conformity to the requirements.Compared with conventional Danshen tablets,Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.Conclusion: Danshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets. |
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| Keywords: | Salvia miltiorrhiza osmotic pump pharmacokinetics Beagle dog |
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