Activity of telithromycin against 26 quinolone-resistant pneumococci with known quinolone-resistance mechanisms |
| |
Authors: | K Nagai D Hoellman T Davies M Jacobs P Appelbaum |
| |
Institution: | Department of Pathology, Hershey Medical Center, Hershey, PA 17033 and;Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA;Tel: +1 717 531 5113 Fax: +1 717 531 7953;E-mail: |
| |
Abstract: | NCCLS agar dilution was used to test activity of telithromycin compared to clarithromycin, penicillin G, ciprofloxacin, levofloxacin, sparfloxacin and moxifloxacin against 26 pneumococci with defined quinolone resistance (type II topoisomerase and efflux) mechanisms. Thirteen strains were penicillin susceptible, six intermediate and seven resistant. Clarithromycin resistance ( mef and/or erm ) was seen in eight strains. Ciprofloxacin MICs (mg/L) were 8–64 compared to 1–32 (levofloxacin), 0.5 ≥ 32 (sparfloxacin) and 0.125–4 (moxifloxacin). Telithromycin MIC50 and MIC90 values (mg/L) were 0.016 and 0.25, with only one strain having an MIC of 2 mg/L. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|