The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats |
| |
| Authors: | B. D. Jaffee J. S. Kerr E. A. Jones J. V. Giannaras M. McGowan N. R. Ackerman |
| |
| Affiliation: | (1) Medical Products Department, Experimental Station, E. I. Du Pont de Nemours & Co., Box 80400, 19880-0400 Wilmington, DE, USA |
| |
| Abstract: | The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were treated for 18 dayswith CSA (100% at 10 mg/kg) or MTX (100% at 0.1 mg/kg). Body weights of drug treated AA rats were increased above untreated AA rats and were similar to non-arthritic controls. AA rats show elevated T helper (W3/25+)/T suppressor (OX 8+) cell ratios (2.0 vs. 3.1,p<0.01). The immunomodulators tested all returned these elevated ratios to control non-arthritic levels. Similarly, these drugs returned the reduced mitogen responses and elevated blood granulocyte numbers toward normal non-arthritic control values. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
