| 脉络宁口服液对血小板聚集及血栓形成的影响 |
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| 引用本文： | 陈钟,王兴旺,蔡莹,戴德哉,杨平,汪征.脉络宁口服液对血小板聚集及血栓形成的影响[J].药学与临床研究,2004,12(4):39-41. |
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| 作者姓名： | 陈钟 王兴旺 蔡莹 戴德哉 杨平 汪征 |
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| 作者单位： | 1. 金陵药业股份有限公司技术中心,南京,210009
2. 中国药科大学,南京,210009 |
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| 基金项目： | 国家“十五”重大专项 (“86 3”计划 )资助项目 |
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| 摘 要： | 目的 研究脉络宁口服液对血小板聚集及血栓形成的影响。方法 采用了血小板聚集试验、抗血栓形成试验、溶栓试验。结果 脉络宁口服液能明显地抑制家兔血小板聚集 ;明显地抑制家兔体内及体外血栓形成 ;对已形成的血栓有溶解作用。结论 脉络宁口服液能够抑制血小板聚集 ,抗血栓形成 ,同时具有一定的溶栓作用。
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| 关 键 词： | 脉络宁口服液 血小板聚集 血栓形成 溶栓作用 |
| 文章编号： | 1007-306(2004)04-39-03 |
| 修稿时间： | 2004年3月30日 |
Effects of Mailuoning Qral Liquid on Platelet Aggregation and Thrombosis |
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| Chen Zhong,Wang Xing-wang,Cai Ying,Dai De-zai,Yang Ping,Wang Zheng Jinling Pharmaceutieal Co.Ltd.Effects of Mailuoning Qral Liquid on Platelet Aggregation and Thrombosis[J].Pharmacertical and Clinical Research,2004,12(4):39-41. |
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| Authors: | Chen Zhong Wang Xing-wang Cai Ying Dai De-zai Yang Ping Wang Zheng Jinling Pharmaceutieal CoLtd |
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| Institution: | Chen Zhong1,Wang Xing-wang1,Cai Ying1,Dai De-zai2,Yang Ping2,Wang Zheng2 1Jinling Pharmaceutieal Co.Ltd |
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| Abstract: | Aim To investigate the effects of mailuoning oral liquid on platelet aggregation, thrombosis and fibrinolysis. Method Platelet aggregation was induced by adenosine diphosphate (ADP) in rabbits. In vivo and in vitro thrombosis, and in vivo fibrinolysis tests were used to evaluate the effects of the drug on the fibrinolysis system. Result Mailuoning oral liquid significantly inhibited ADP-induced rabbit platelet aggregation; it reduced thrombus weight and length significantly; it also showed a strong enhancement on fibrinolysis. Conclusion Mailuoning oral liquid could inhibit rabbit's platelet aggregation induced by ADP and also increase fibrinolysis. |
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| Keywords: | Mailuoning oral liquid Platelet aggregation Thrombosis Fibrinolysis |
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