H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat |
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| Authors: | Anderson Catriona M H Grenade Danielle S Boll Michael Foltz Martin Wake Katherine A Kennedy David J Munck Lars K Miyauchi Seiji Taylor Peter M Campbell Frederick Charles Munck Bjarne G Daniel Hannelore Ganapathy Vadivel Thwaites David T |
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| Affiliation: | Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK. |
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| Abstract: | |
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| Keywords: | ABA, aminobutyric acid BCECF, 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein BBMV, brush-border membrane vesicles bp, base pair cAMP, 3′,5′-cyclic monosphosphate EIPA, N-(ethyl-N-isopropyl)-amiloride GABA, γ-aminobutyric acid hPAT1, human proton-coupled amino acid transporter 1 hPepT1, human intestinal di/tripeptide transporter HRPE, human retinal pigment epithelial Ki, inhibition constant Km, Michaelis constant LYAAT1, lysosomal amino acid transporter-1 MeAIB, methylaminoisobutyric acid MeLeu, methyl-leucine mPAT1, mouse proton-coupled amino acid transporter 1 NHE, Na+/H+ exchanger PAT, proton-coupled amino acid transporter PCR, polymerase chain reaction PepT1, di/tripeptide transporter pHi, intracellular pH rBAT, related to b0,+ amino acid transporter VIP, vasoactive intestinal polypeptide |
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