血清雌二醇睾酮水平与女性乳腺癌的关系

目的 观察女性乳腺癌患者血清雌二醇(E2)和睾酮(T)的变化.方法 采用放射免疫分析(RIA)法,对120例女性乳腺癌患者、40例乳腺良性病变患者及30例正常健康妇女血清E2、T浓度进行检测.结果 乳腺癌患者的BMI值和血清E2、T水平明显高于乳腺良性病变组和正常对照组(P＜0.05);不同临床分期乳腺癌患者BMI及血清E2、T浓度与TNM分期之间各项指标均无显著性差异(P＞0.05);乳腺癌患者有无腋窝淋巴结转移其BMI值及血清E2、T检测结果均无显著性差异(P＞0.05);血清E2、T浓度在乳腺癌患者绝经前、后存在显著性差异(P＜0.05或P＜0.01).结论 高水平雌激素与乳腺癌的发病关系密切,高水平雄激素与乳腺癌的发生亦存在相关关系.在诱导乳腺癌的协同作用中,雌激素是主要的致癌因子,而雄激素主要起到促进乳腺癌形成和加速其发展的作用.

ESTRADIOL TESTOSTERONE AND FEMALE MAMMARY CANCER

Objective To observe the changes in the levels of estradiol(E_2) and testosterone(T).Methods Radioimmunoassay(RIA) was used to detect the levels of E_2 and T of 120 cases of female mammary cancer,40 cases of malignant mammary changes and 30 formal cases.Results The BMI value and the levels of E_2 and T in the cases of mammary cancer were found higher than those in cases of malignant mammary changes and normal cases(P<0.05).Analysis of variance showed that no significant differences existed between the indexes of BMI,E_2 and T and the TNM stages(P>0.05).The levels of E_2 and T showed significant differences both at the premenopausal and postmenopausal stages(P<0.05,or P<0.01).Conclusion High level of E_2 is closely related to the attacks of mammary cancer.High level of androgen is also related to the attacks of mammary cancer.E_2 acts as the key carcinogenic factor,while androgen help to promote the development and the attacks of mammary cancer.