消化性溃疡愈合过程中粘膜血流量的变化

CHANGES OF MUCOSAL BLOOD FLOW IN THE HEALING PROCESS OF PEPTIC ULCER

Changes of gastric-duodenal mucosal blood flow (GDMBF) in the healing process of 81 patients with gastric ulcer and 130 with duodenal ulcer and 9 with active ulcer induced by gastric polypectomy were studied by endoscopic laser Dopple flowmetey, 108 cases of no gastric-duodenal lesions were used as controls.In normal sut mucosal blood flow at the angle and antrum of the lessor curvature and at the anterior wall of the duodenal bulb was the smallest (P<0.01).In patients with gastric ulcer, GMBF was decreased significantly (P<0.01) at active stage and increased at healing stage.GDMBF was increased significantly (P<0.01) at active stage and returned to the normal at the healing stage of duodenal ulcer.GDMBF was unchanged in the healing process of the active ulcer induced by gastric polypectomy.The mucosal blood flow at ulcer centre and margin was decreased significantly at active stage and increased markedly at healing stage as compared with that of surrounding mucosa.We conclude that GMBF plays an important role in the developing and healing process of peptic ulcers