| 糖酵解与肿瘤 |
| |
| 引用本文： | 许晓巍,孟祥军,王椿.糖酵解与肿瘤[J].国外医学(肿瘤学分册),2011(8):585-589. |
| |
| 作者姓名： | 许晓巍 孟祥军 王椿 |
| |
| 作者单位： | 上海交通大学附属第一人民医院血液科,200080 |
| |
| 摘 要： | 肿瘤细胞主要通过糖酵解获取能量促进其生长，这与线粒体DNA变异和抑癌基因突变有关。抑制糖酵解具有抑制增殖和杀伤肿瘤细胞的作用。糖酵解限速酶和低氧诱导因子有望成为治疗肿瘤的新靶点。
|
| 关 键 词： | 糖酵解 肿瘤 缺氧诱导因子1 |
Glycolysis and tumor |
| |
| XU Xiao-wei,MENG Xiang-jun,WANG Chun.Glycolysis and tumor[J].Foreign Medical Sciences (Cancer Section),2011(8):585-589. |
| |
| Authors: | XU Xiao-wei MENG Xiang-jun WANG Chun |
| |
| Institution: | .( Department of Hematology, First People＇s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China) |
| |
| Abstract: | Tumor cells obtain energy mainly by glycolysis to maintain growth and proliferation. It is related to the DNA mutations of mitochondria and anti-oncogene mutations. Inhibition of glyeolysis can inhibit proliferation and kill tumor cells. The rate-limiting enzyme of glyeolysis and hypoxia inducible factor may be the new targets for cancer therapy. |
| |
| Keywords: | Glycolysis Neoplasms Hypoxia-inducible factor 1 |
| 本文献已被 维普 等数据库收录！ |
