急性心肌梗死不同梗死部位与冠脉病变血管血浆hs-CRP和Hcy变化的临床观察

目的探讨急性ST段抬高型心肌梗死（STEMI）不同梗死部位和冠脉病变血管血浆hs-CRP、Hcy的变化。方法 69例急性心肌梗死患者根据心电图、心肌坏死标记物及冠脉造影分为急性ST段抬高广泛前壁心肌梗死组37例和急下壁心肌梗死组32例。于发病24h内抽取静脉血行血浆hs-CRP、Hcy检测。结果急性ST段抬高广泛前壁和下壁心肌梗死早期血浆hs-CRP和Hcy均高于正常值,且广泛前壁心肌梗死组的hs-CRP和Hcy要高于下壁心肌梗死组,但两组比较差异无统计学意义（P〉0.05）。结论 hs-CRP和Hcy是急性心肌梗死的危险因素,并且可反映心肌损害和血管病变的程度。

Clinical observation to different locations of AMI and hs-CRP and Hcy in plasma

Objective To explore the relationship between the different locations of acute myocardial infarction with elevated ST segment（STEMI） as well as coronary narrowing and the levels of high-sensitive C-reactive protein（hs-CRP） and hemoeysteine（Hcy） in plasma.Methods Sixty-nine patients of STMI were divided into group-1（n=37, the infarction was located in the wide anterior wall） and group-2（n=32, the infarction was located in the inferior wall） by ECG and coronary angiogram. The hs-CRP and Hcy in plasma were tested for all of the patients with venous blood samples taken within 24 hours of the AMI.Results The hs-CRP and Hcy was elevated over the normal level significantly in both of the two groups（P〈0.05）. That was higher in group-1 than that of group-2 but the difference was not significant（P〉0.05）.Conclusion Both hs-CRP and Hcy are risk factors of AMI and may reflect the extent of the myocardial injury and coronary narrowing.