新生儿窒息血清心肌酶活性检测46例临床分析

目的分析窒息新生儿的血清心肌酶活性变化,探讨新生儿窒息血清心肌酶活性检测的临床价值。方法观察组为笔者所在医院46例窒息足月新生儿,对照组为同期46例健康足月新生儿,胎儿娩出后均进行出生后Apgar评分,测定脐血血清中门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶心肌同工酶（CK-MB）、α-羟丁酸脱氢酶（α-HBD）的水平。结果观察组新生儿的脐血血清AST、LDH、CK、CK-MB、α-HBD的检测值均高于对照组,差异有统计学意义（P〈0.05）。结论新生儿脐血血清心肌酶活性检测可作为判断新生儿窒息缺氧的客观指标,窒息新生儿心肌酶活性检测可反映新生儿窒息后心肌损害及严重程度,用于早期诊断治疗,预防病情恶化并改善新生儿预后情况。

Clinical analysis of activity of myocardial enzyme in 46 cases neonatal asphyxia

Objective To analyze the activity of myocardial enzyme in neonatal asphyxia and observe the clinical value of activity of myocardial enzyme in neonatal asphyxia.Methods 46 cases for the hospital group term neonates with asphyxia,the control group for the same period 46 cases of healthy full-term newborns,the baby is delivered Apgar score after birth were measured in cord blood serum aspartate aminotransferase（AST）,lactate dehydrogenase（LDH）,creatine kinase（CK）,creatine kinase myocardial isoenzyme（CK-MB）,α-hydroxybutyrate dehydrogenase（α-HBD） levels.Results The newborn＇s cord blood serum AST,LDH,CK,CK-MB,α-HBD test values were higher,the difference was significant（P〈0.05）.Conclusion Neonatal cord blood serum enzyme activity assay could be used as an objective indicator of neonatal asphyxia,myocardial enzyme activity in neonatal asphyxia neonatal asphyxia test can reflect the severity of myocardial damage and,for the early diagnosis and treatment, prevention of illness deterioration of the situation and improve neonatal outcomes.